I am not saying to do nothing, but a full reset most likely won't fix it. More that there may be a combination of things it takes to get it up and running. I was suggesting that some of that may be waiting for fixes, but not everything will.
For example, I would see if a controlled shut down, pull the power for a while, and then power on boot helps anything. (not just rebooting) Maybe some of the issues will clear up after the nightly maintenance. I might even be tempted to submit a help ticket if you think there is even a 1% possibility it is a hardware rather than software issue.
You could even have a bad Zwave device killing everything else, and not know it.
I didn't read through your history, so I am not sure what all you have done, but there are some that were able to eventually work though these issues and it was fine after that. So I would keep trying things as people post what worked or helped.
I know it is frustrating, I am having some issues with my hub that I have never seen before in the 18 months or so I have been on here. Luckily I could roll back to a more stable update, not everyone has that option.