Maybe.
Some minisplit accept normal thermostat wires, but most don't. In that case you could use a Zwave thermostat.
The other option is usually a cloud connected dongle that makes them smart. There are a couple community based drivers for a couple brands on here. Midea Mini Split Wifi Support and [RELEASE] Unified Thermostat Driver - MELCloud, MELView, Kumo Cloud and more if you want as a couple examples. There might be others, but these were the first two that popped into my head, so forgive me if I forgot one.
