Couple questions:
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What devices do you have?
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How long have these devices been in use? Was it working better before and then stopped working, or has this been an ongoing problem?
A few things that you can look at:
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For any devices that report power/energy usage, reduce the frequency of reports.
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Look at the Stats column in Z-Wave details for high or increasing numbers for Route changes or PER and for high RTT Avg, which might help track down problem devices or unstable mesh. (You might find the Z-Wave Mesh Tool useful.)