Thanks for the quick insight. I did make sure to hit Update and then Done, but I think it was related to something else.
I modified the IP address in HE to a static route earlier and also reserved the IP in my router table, but was having trouble connecting to HE in my app after. I was able to access via direct IP to the static route I changed, though, so figured it was caching issue. I thought maybe this was related but not sure how. Found an unrelated post talking about static IP and changed HE back to DHCP after configuring the IP at the router and re-setup the Lutron Integrator then updated the Echo Skill and, boom.. that did the trick.
So, to confirm, one does not need to enable the Lutron skill in Amazon.
Still getting the hang of this (HE). So powerful and have barely scratched the surface from moving over from Wink.