Yes you can. There is a native google chromecast integration that uses TTS built into the hub. The HE supports many languages. There is also another custom integration for TTS, search our forums.
I use google minis for this. I think alexa also works
You can play an audio file directly. Stick it in the files section of your hub and then just address it directly as a playTrack url within a Custom Action to play it (hub_ipaddress/local/your_sound.mp3 should do the trick, as long as the device selected can play the file type).